Moreover, DDD-028 was also able to maintain the physiological levels of NF proteins in the sciatic nerve and in the plasma, which have been recently proposed as a biomarker in chemotherapy-induced polyneuropathy.9,45,50,92 Because chemotherapy-associated toxicity leads to a primarily axonal polyneuropathy,15 injured peripheral neurons release NF-L, which subsequently leads to increased blood NF-L concentrations.9,24,40 Here, we observed that the increase of plasma NF-L levels caused by paclitaxel in mice was significantly reduced by the administration of DDD-028. The gene discussed is NEFL; the disease is polyneuropathy.