Haupt andhis collaborators, in 2015, were the first to demonstratethat fluorescence nanoMIPs can be used for cell and tissue imagingby localizing and quantifying target biomolecules (hyaluronic acid)on cells.74 After this seminal work, fluorescenceimaging was further applied for the in vivo studyof (i) epidermal growth factor receptor (EGFR) in breast cancer celllines,63 (ii) hyaluronic acid (HA) in humanskin keratinocytes,94 and (iii) β2microglobulin (B2M) as a means to detect senescent cells in mice.64 This evidence concerns the gene EGFR and breast cancer.