PIK3CA and cancer: Pathways in cancer encompass many inflammatory factors that mediate immune responses by a variety of mechanisms, and there are multiple targets in this pathway that are relevant to the pathogenesis of neuroinflammation, such as the Potassium channel AKT1 (AKT1), Nitric oxide synthase, inducible (NOS2), Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), Matrix metalloproteinase-9 (MMP9), Nuclear factor NF-kappa-B p105 subunit (NFKB1), Mitogen-activated protein kinase 1 (MAPK1), and Prostaglandin G/H synthase 2 (PTGS2).