New molecularly defined RCC subtypes are named and described: Eosinophilic solid and cystic RCC, elonging C (ELOC)-mutated RCC (formerly denominated Transcription elongation factor B (TCEB1)-mutated RCC), ALK-rearranged RCC, SMARCB1-deficient medullary RCC, TFEB-altered RCC, and fumarate hydratase (FH)-deficient RCC (formerly hereditary leiomyomatosis (HLRCC) syndrome-associated RCC. The gene discussed is TFEB; the disease is renal cell carcinoma.