Some entities are now regarded as independent types of RCC with specific clinical and molecular features, such as sporadic FH-deficient RCC, tubulocystic RCC, ESC RCC, clear cell papillary RCC, SMARCB1-deficient RCC, and microphthalmia-associated transcription factor (MiTF) family RCC [25]. This evidence concerns the gene SMARCB1 and renal cell carcinoma.