We speculate that Nrf2 may inhibit the activation of the NLRP3 inflammasome and pyroptosis in alveolar cells by regulating oxidative stress injury in BPD; therefore, we provide insights into a promising treatment strategy via regulation of the Nrf2/NLRP3/Caspase-1 signaling pathway. The gene discussed is NLRP3; the disease is bronchopulmonary dysplasia.