NLRP3 and bronchopulmonary dysplasia: TUNEL and NLRP3 co-staining showed that NLRP3 activation–induced pyrodeath of alveolar cells in the BPD group was significantly increased (P < 0.0001), and the number of pyroptosis-positive cells in the TBHQ group was significantly lower than that in the BPD group (P < 0.01); conversely, the Nrf − / − group had the opposite result, and the number of pyroptosis-positive cells was significantly increased at P5 (P < 0.0001) (Fig. 6c, d).