Furthermore, a previous report showed that in neonatal mice, hyperoxia exposure and overexpansion during mechanical ventilation were found to help activate the NLRP3 inflammasome, significantly increase the expression and activation of Caspase-1 and IL-1β proteins, and induce pyroptosis in the lung tissue of BPD mice. This evidence concerns the gene NLRP3 and bronchopulmonary dysplasia.