We speculate that Nrf2 may inhibit the activation of the NLRP3 inflammasome and pyroptosis in alveolar cells by regulating oxidative stress injury in BPD; therefore, we provide insights into a promising treatment strategy via regulation of the Nrf2/NLRP3/Caspase-1 signaling pathway. This evidence concerns the gene CASP1 and bronchopulmonary dysplasia.