Whereas high-risk for fibrosis was the greatest influence over liver-related mortality in both MAFLD and NAFLD (HR 17.15, 95% CI 4.55–64.65 and HR 9.26, 95% CI 1.84–46.33, respectively), the other covariates with most influence were alcohol-related liver disease (HR 4.50, 95% CI 1.89–10.75) and chronic kidney disease (HR 2.92, 95% CI 1.21–7.01) for MAFLD, while they were high C-reactive protein (CRP) (HR 4.47, 95% CI 1.35–14.77) and insulin resistance (HR 3.57, 95% CI 1.35–9.42) for NAFLD. Here, CRP is linked to metabolic dysfunction-associated steatotic liver disease.