Furthermore, in published studies, few data on baseline characteristics and outcomes concerning gender and sexual hormone status of participants is included: preoperative levels of testosterone or estrogen, postoperative FSH, LH or GH deficiency, or postoperative frequency of SIADH are not reported in any study and only single studies reported postoperative hyperprolactinemia [94], postoperative panhypopituitarism [83], postoperative ACTH and TSH deficiency [9], and any endocrinological deficit [55] stratified by gender (Supplementary Table 1). This evidence concerns the gene PLOD1 and panhypopituitarism.