CD40LG and diffuse large B-cell lymphoma: The WHO-5 also does not exclude EBER-negative cases from ECPEL and notes that the distinction between nodal involvement by ECPEL and HHV8+DLBCL may be difficult [4 The ICC states that HHV8+DLBCL and NOS should be favored in EBV-negative cases with cytoplasmic IgM, lambda, and/or associated with MCD.