In contrast to BL, mutations in the ID3-TCF3 pathway, recognized as the biological hallmark of BL, are not detected in HG/LBCL-11q. The mutational landscape of HG/LBCL-11q is closer to that of DLBCL of GCB-type, and GNA13 mutations are observed in about 50% of cases [21, 22]. Here, TCF3 is linked to Burkitt lymphoma.