As shown in Table 1; Figure S1B,C, RNF146 overexpression was significantly associated with tumour size (p = 0.039), depth of invasion (p = 0.003) and poor overall survival (median overall survival: 22.10 vs. 31.35 months, p = 0.0216) in GC patients. This evidence concerns the gene RNF146 and gastric cancer.