For instance, CUL4A mediates the ubiquitination of LATS1 to regulate YAP activity in hepatocellular carcinoma,37 AGK inhibits the activation of the Hippo pathway proteins in GC38 and CD44 functions upstream of the Hippo signalling pathway and attenuates its activation in glioblastoma.39 This evidence concerns the gene CUL4A and glioblastoma.