While our results support a beneficial role of reducing microglia activation by inhibiting TPL2 in a tauopathy model, other recent therapeutic approaches have focused on boosting microglia activation to accelerate clearance of disease-related protein aggregates, such enhancing TREM2-mediated, stimulation of microglia phagocytosis of Aβ (Fassler et al., 2021; Wang et al., 2020). Here, TREM2 is linked to tauopathy.