Mutations in WAVE and other WRC subunits have been linked to various neurodevelopmental disorders in humans, including neurodevelopmental disorder with absent language and variable seizures, developmental and epileptic encephalopathy-65, and Alzheimer’s disease (Begemann et al., 2021; Conway et al., 2018; Ito et al., 2018; Kirkpatrick et al., 2017; Kramer et al., 2022; Kumar et al., 2013; Olive et al., 2020; Rottner et al., 2021; Shimojima Yamamoto et al., 2021; Sims et al., 2017; Srivastava et al., 2021; Zhao et al., 2021; Zweier et al., 2019). The gene discussed is WASF1; the disease is neurodevelopmental disorder.