Moreover, CABLES1 was identified in a genome-wide association study (GWAS) as a gene associated with obesity-related phenotypical traits [15,16], and was recently proposed as a top candidate, adipose tissue-specific, obesity-risk regulatory SNP-containing gene in an epigenomic and transcriptomic GWAS meta-analysis study [17]. This evidence concerns the gene CABLES1 and obesity due to melanocortin 4 receptor deficiency.