CD8+ T cells are related to the liquefaction of basal cells, and it is believed that the immune microenvironment of OLP lesions has changed, especially in CD8+ T cells, which produce a complex network of cytokines and chemokines, such as IFN-γ, TNF-α, IL1α, and IL17, among others (Firth et al., 2015; Ke et al., 2017; Piccinni et al., 2014; Shaker and Hassan, 2012; Viguier et al., 2015). The gene discussed is CD8A; the disease is oral lichen planus.