We study VSTMB for both sporadic MCI and prodromal familial AD—caused by the single mutation E280A of PSEN1 gene (Lopera et al., 1997)—to identify the changes in network topology due to the disconnecting pathology of AD, while also considering the age-related factors that distinguish the familial and sporadic forms of AD. The gene discussed is PSEN1; the disease is Alzheimer disease.