IL6 and Insulin resistance: Meanwhile, the signaling axis that IL-6 regulates insulin resistance is considered, IL-6/IL-6Rα/gp130 signaling activates JAK/STAT3 phosphorylation, and p-STAT3 further induces the inhibition of cytokine signaling 3 (SOCS3) gene transcription by binding to its promoter, whereas SOCS3 is an inhibitor of IL-6/JAK/STAT3 signaling.