Microinjected, intracellular MANF protein with a mutated CXXC motif CKGS in the SAP domain was inactive against etoposide- or thapsigargin-induced apoptosis in SCG or dorsal root ganglion (DRG) sensory neurons in vitro as well as in vivo in a rat model of stroke, where mutated MANF CKGS was injected into brain parenchyma (133). The gene discussed is MANF; the disease is stroke disorder.