The ability of CDNF to attenuate pro-inflammatory cytokines was also demonstrated in the intracerebral hemorrhage model, where administration of CDNF reduced levels of IL-6, TNF-α, IL-1β, and IFN-γ, while increasing the level of IL-10 in the peri-hematoma striatum on days 1 and 3 after hematoma induction (94). This evidence concerns the gene CDNF and hematoma.