In another study, increased levels of GRP78 were also demonstrated in the cingulate gyrus and parietal cortex of patients with dementia with Lewy bodies and Parkinson’s disease dementia relative to patients with Alzheimer disease, suggesting that UPR activation is more pronounced in cases with Lewy body pathology or when Lewy pathology is present with plaque pathologies (45). The gene discussed is HSPA5; the disease is dementia.