The core targets with topological significance, including TNF, tumor protein (TP) 53, albumin (ALB), IL-6, AKT serine/threonine kinase (AKT)1, vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), and toll-like receptor (TLR) 4, might play an important role in the molecular mechanism of AJH against ALI. Here, AKT1 is linked to acute respiratory distress syndrome.