TNF and acute respiratory distress syndrome: Preliminarily, AJH was hypothesized to treat ALI by modulating the core targets, including TNF, TP53, ALB, IL-6, AKT1, MAPK, and TLR4, and related signaling pathways (PI3K-Akt, AGE-RAGE, and JAK-STAT), which laid the foundation for the specific molecular mechanism of ALI treatment by AJH.