MAPT and Alzheimer disease: Deposition of Aβ and hyperphosphorylated tau proteins is a crucial event in AD as pathology several studies demonstrated the pharmacological potencies of ITCs against these two hallmarks and their toxicity by intervene in its cascade such as APP cleavage, BACE1 expression, oligomerization of seeded proteins, phosphorylation and dephosphorylation assembly, etc. (Morroni et al., 2018; Asif et al., 2022).