Thrombomodulin (TM) is an important cofactor in the anticoagulant pathway that exerts anticoagulation effects in vivo, however, its expression is decreased during the development of septic-disseminated intravascular coagulation.17 Recombinant human soluble TM (rTM) can inhibit NET formation by binding to histones.18 Previously, we reported that injecting rTM into a mouse model of endotoxin shock improved the survival rate and inhibited NET formation in both lung and liver tissues.19 However, the effects of rTM on the kidney remain controversial. This evidence concerns the gene THBD and Disseminated intravascular coagulation.