Myokines are thought to be responsible for some of the various mechanisms of suppressing cancer growth due to exercise, and are considered to have cancer-growth-suppressing effects involving secreted protein acidic and rich in cysteine (SPARC).60 SPARC levels decrease with aging and inactivity.60 Although skeletal muscles are present throughout the body, cancer metastasis to the muscles is uncommon, and antioxidants and enzymes present in myocytes might be important for suppressing cancer growth. The gene discussed is SPARC; the disease is cancer.