A study using an arteriosclerosis-prone murine model showed that, although no change was found in the blood lipoprotein profile, which is a risk factor for arteriosclerosis, the area of arteriosclerotic plaques significantly decreased upon sustained exercise training.16 In addition, a clear decrease in expression levels of vascular cell adhesion molecule 1 and monocyte chemoattractant protein 1, which induce arteriosclerosis, was observed. This evidence concerns the gene CCL2 and arteriosclerosis.