To date, nectin-4 has been studied as a potential biomarker mainly in the field of cancer research, with a demonstrated overexpression in a number of tumor types, including breast, lung, urothelial, colorectal, pancreatic and ovarian cancer.8,25 Serum nectin-4 concentrations were shown to be elevated in patients with these cancers. The gene discussed is NECTIN4; the disease is neoplasm.