To gather relevant literature, a combination of specific keywords and medical subject headings (MeSH) terms such as “heart failure,” “heart failure, systolic,” “heart failure, diastolic,” “dyspnea, paroxysmal,” “edema, cardiac,” “cardio-renal syndrome,” “LCZ696," “LBQ657” (an active metabolite of sacubitril), “neprilysin inhibitor,” “Entresto,” or “valsartan and sacubitril” were used. Here, MME is linked to heart failure.