Furthermore, at the basal lateral of the colon epithelium, TLR5 specifically recognizes flagellin and activates nuclear factor (NF)-κB, which induces the secretion of chemokines IL-8 and macrophage inflammatory protein 3 (MIP3) in model human IECs (prepared by culturing the colonic cell line T84 on collagen-coated permeable supports) [67, 68], the T cell transfer colitis model [69], and the serum of patients with CD [70]. Here, CCL23 is linked to colitis.