One study of patients with cirrhosis (without HCC: n = 64; CP class B/C, 73.4%) revealed that plasma IGF-1 levels (mean: 80.0, 62.7, and 32.6 ng/mL for CP class A, B, and C, respectively) were inversely correlated with the CP score, and the L-IGF1 group had lower 2 years survival rates than the H-IGF1 group (13). Here, IGF1 is linked to hepatocellular carcinoma.