On the other hand, tumors arising from the PAX8 KD background presented as high-grade undifferentiated carcinomas, with extensive areas of necrosis and morphological appearance reminiscent of neuroendocrine differentiation, in keeping with a large-cell phenotype, but no morphological evidence of rhabdoid dedifferentiation (Figures 1H and S2F). The gene discussed is PAX8; the disease is carcinoma.