PAX8 and nonpapillary renal cell carcinoma: However, MRTs in the kidney originate from a different cell type than ccRCCs suggesting that the molecular similarities of PAX8 inhibition-resistant ccRCC cells and rhabdoid tumors is likely to reflect the shared SMARCB1 mutation status and general dedifferentiation rather than the acquisition of a rhabdoid ccRCC phenotype.47