SPOP and neoplasm: Taken together, all these results suggest that in Drosophila, Gli2 and SPOP can substitute Ci and HIB to mediate the same tumor-like eye phenotype, in mammalian cells, hRpb7 stability is similarly regulated by Gli2 and SPOP, indicating that our model and the identified rescue genes are useful for future study of Hh- and SPOP-related tumorigenesis.