Of note, simultaneous overexpression of Ci and DIAP1 or P35 which blocks apoptosis did not cause tumor-like eye phenotype (Figure S1), suggesting Ci and hib RNAi together-mediated tumor-like eye phenotype may be only partially through inhibiting apoptosis, except that, other unidentified process must be involved in driving the big eye phenotype. Here, DIAPH1 is linked to neoplasm.