As shown in Figures 5G–5I′′′, co-overexpression of Ci−3P and hib RNAi blocked Grim/Rpr but not Hid-mediated apoptosis, implying that the tumor-like eye may be related to disability of apoptosis mediated by Grim/Rpr but not Hid in our case. The gene discussed is EXTL3; the disease is neoplasm.