EXTL3 and neoplasm: For Rpr, we surprisingly found that overexpression of Ci or hib RNAi alone could not, but they together completely blocked Rpr-mediated apoptosis, suggesting Ci and hib RNAi synergistically achieve the tumor-like eye phenotype possibly partially through inhibiting Rpr-mediated apoptosis (Figures 5G–5I′′′).