As shown in Figure 2, we found SPOP but not SPOPΔMATH and SPOPΔBTB could rescue the tumor-like eye phenotype, SPOPΔMATH and SPOPΔBTB even manifested the dominant negative effect shown by boosting the tumor-like eye phenotype (Figures 2C and 2D), indicating that both MATH and BTB domain are needed to inhibit the eye tumorigenesis. Here, SPOP is linked to neoplasm.