,50 To test whether HIB/SPOP E3 ligase activity is needed to inhibit the tumor-like eye phenotype, in co-overexpression of Ci−3P and hib RNAi background, we first check the rescue effects of two SPOP E3 ligase-dead truncated forms, SPOPΔMATH and SPOPΔBTB, respectively. Here, SPOP is linked to neoplasm.