SORCS3 showed downregulation in SLE patients with ESR (p = 4.5E−3, log2FC = −1.57), snRNP (p = 2.2E−4, log2FC = −2.10), AHA (p = 4.8E−4, log2FC = −1.77), and anti-Smith (p = 8.6E−3, log2FC = −1.53). The gene discussed is ESR1; the disease is systemic lupus erythematosus.