More so, ETBF could induce the development of CRC cells from tumor Cancer stem-like cells (CSCs), via activating toll-like receptor 4 (TLR4), and promoting the expression of Jumonji domain-containing 2B (JMJD2B) through T cell nuclear factor 5 (NFAT5) stimulation (Fig. 1C). This evidence concerns the gene TLR4 and colorectal carcinoma.