TCF4 and adenomatous colon polyp: As the structure of E-cadherin changes, β-catenin (which is normally bound to the E-cadherin intracellular domain) dissociates, causing the abnormally expressed β-catenin to escape the regulation of the adenomatous colon polyp (APC) protein β-catenin enters the nucleus to form a complex with Transcription Factor 4 (TCF4) (Chung et al., 2018).