IFNG and hypertrophy: Since pulmonary IFN-γ+NK1.1+ cells were significantly increased after HF, and since IFN-γ exerts an important role in HF development (32, 41), we examined the role of NK1.1+ cells on LV hypertrophy and dysfunction in control and HF mice by depleting NK1.1+ cells using anti-NK1.1 antibodies starting ten days after TAC surgery (Figure 2A).