At present, five main types of tumor immunotherapy are known: 1) molecular targeted therapy; 2) immune checkpoint inhibitors (PD-1/L1 and CTLA-4 inhibitors); 3) adoptive cellular immunotherapy (CAR-T cellular immunotherapy, TCR-T cellular immunotherapy, etc.); 4) cytokine therapy; 5) tumor vaccines. This evidence concerns the gene CTLA4 and neoplasm.