It has been previously shown that both c-Myc and SIRT1 are highly elevated in major types of cancer cells, where c-Myc may elicit apoptosis or premature senescence through p53-dependent pathway (Vafa et al., 2002; Dominguez-Sola et al., 2007; Menssen et al., 2007; Campaner et al., 2010). The gene discussed is SIRT1; the disease is cancer.