We found positive correlations between parameters of macular oedema (i.e., CRT and ILM-IPL) and intraocular inflammatory mediators including GROβ, Granzyme B, Flt-3 L, IL-33, PD-L1, and G-CSF, suggesting that they may contribute to retinal vascular leakage, fluid accumulation, and neuronal damage in RVO. Here, CD274 is linked to macular retinal edema.