The present study revealed that the dephosphorylation of mitochondrial p-GPX4Ser2 participated in Sora-induced ferroptosis in HCC by inducing mitochondrial p53 translocation into the nucleus and PP2A-B55β (encoded by the PPP2R2B gene) was involved in p-GPX4Ser2 dephosphorylation. Here, TP53 is linked to hepatocellular carcinoma.