GPX4 and hepatocellular carcinoma: Distinct from the ferroptosis resistance effects observed in HepG2 cells overexpressing WT and the other mutations of GPX4, Sora-induced LPO accumulation (Figure 4G) and cell death (Figure 4H) were only observed in S2A cells, suggesting that p-GPX4Ser2 dephosphorylation accelerated ferroptosis in HCC.