As shown in Figure S1B-D, the expression of the solute carrier family 7 member 11 (SLC7A11) subunit of system Xc- and the level of GSH were decreased in Sora-treated HCC cells, whereas there were no significant changes observed in the expression of transferrin receptor (TFRC), Fe3+ reductase six-transmembrane epithelial antigen of prostate 3 (STEAP3), ferritin heavy chain 1 (FTH1), and the iron-pumping protein ferroportin 1 (FPN1) in Sora-treated HCC cells. The gene discussed is STEAP3; the disease is hepatocellular carcinoma.