Similarly, compared to that in peritumor tissues, the expression of ferroptosis-inducing genes, including PTGS2, HMOX1, TFR2, and NCOA4, was down-regulated in tumor tissues, whereas ferroptosis-suppressor genes SLC7A11 and FTH1 were upregulated (Figure 1B). The gene discussed is TFR2; the disease is neoplasm.