As shown in Figure 2B and Figure S1A, Sora-induced cell death cannot be rescued by the apoptosis inhibitor (Zvad), necroptosis inhibitor (Nec-1), or autophagy inhibitor (chloroquine, CQ) (Figure 2B), but rescued by the co-treatment of Fer-1, indicating that Sora specifically induced ferroptosis in HCC. Here, PCSK1 is linked to hepatocellular carcinoma.