MAPT and Alzheimer disease: We examine herein whether Alzheimer's pathology can be mitigated by ultrasound to (i) investigate the efficacy of repeated bilateral FUS for the reduction of human total tau and amyloid plaques from the 3xTg-AD mice that display both plaque and tangle pathology in the hippocampus, (ii) establish the functional imprint of the pathological amelioration attributed to FUS module by Morris Water Maze (MWM) assessment and (iii) determine the interplay of pathological changes with cholesterol trafficking 32-35.