PTK2 and hepatocellular carcinoma: Additionally, the orthotopic HCC models showed that the impact of knockdown or overexpression of TLR4 or PTK2 on HCC metastasis was less significant in the KLF7 non-manipulated state than in the KLF7 manipulated state, further demonstrating that the TLR4 and PTK2 effects are downstream of KLF7 (Figure S6).