HMGB1 and hepatocellular carcinoma: To explore the role of KLF7 in HMGB1-mediated HCC development and metastasis, we performed hepatocyte-specific knockout of Klf7 in Klf7fl/fl mice via tail vein injection of AAV8-TBG-Cre vectors in the early stage of DEN/CCl4 treatment (Figure 7E-F).