In thyroid cancer, a recurrent fusion between the thyroid adenoma-associated (THADA) gene on chromosome 2 and the LOC389473 gene on chromosome 7 located 12 kb upstream of the IGF2BP3 gene contributes to high expression of IGF2BP3, activating the insulin like growth factor 1 receptor (IGF1R) signaling and facilitating the proliferation, invasion, and transformation of thyroid cancer cells 106. The gene discussed is IGF1R; the disease is thyroid gland carcinoma.