IGF2BP2 and colorectal carcinoma: Subsequently, upregulated IGF2BP2 binds to msh homeobox 1 (MSX1) and jumonji and AT-rich interaction domain containing 2 (JARID2) to form a LINC01021-IGF2BP2-MSX1/JARID2 signaling axis, which contributes to CRC tumorigenesis and progression 78.