CD8A and neoplasm: Combined with Mn3O4 mediated-TME modulation, this synergistic effect induced a workable ICD, resulting in reprogramming of M2-like macrophages to M1-like, maturation of dendritic cells (DCs), activation of CD8+ T cells, secretion of inflammatory cytokines TNF-α and IFN-γ, and ultimately initiation of a powerful anti-tumor immune response.