Neu-Nos2 and Neu-Isg15 were defined as N1-like neutrophils with anti-tumor activity owing to their high expression of Nos2, Isg15, or Icam135-37, whereas Neu-Cxcr2 and Neu-Mmp9 were defined as N2-like neutrophils with pro-tumor activity and characterized by the expression of Cxcr2 or Mmp938, 39. This evidence concerns the gene NOS2 and neoplasm.