Similar to IDH-mutant astrocytomas, the IDH-wild-type glioblastomas which acquired MMR mutations had significantly higher ΔTMB (62.7 ± 20.1) compared to those without MMR mutations in the recurrent specimen (3.1 ± 0.4; P < .0001) (Figure 4). Here, MRC1 is linked to astrocytoma (excluding glioblastoma).