LEPR and cancer: Yoda1, the pharmacological agonist of Piezo1 has been used in the study of the cardiovascular system, bone homeostasis, iron metabolism, and cancer therapy since 2015.[58, 61, 62, 63] In this study, we found that Yoda1 significantly accelerated periodontal tissues growth via activation of Lepr+ cells (Figure 7), suggesting that Yoda1 may be an effective therapeutic target to accelerate periodontal repair and regeneration.