In total, six gene pairs were used to construct COVPRIG, including RIT2 and OAS1, HOXA5 and MLLT11, SLC1A2 and FAM189A2, LOXL1 and NCAPG, C21orf62 and GOLGA8A, and UBE2S and NRXN1. The biological implications of some of these genes in GBM have been explored. This evidence concerns the gene HOXA5 and glioblastoma.