TNF and neoplasm: The relationship between ICDRS and enriched hallmark pathways was demonstrated that abundant pro-oncogenic pathways, such as MYC signal pathway, as well as cell cycle processes pathways, such as DNA repairment and G2M checkpoint pathways were negatively linked to ICDRS, while some tumor suppression pathways, including TNF-alpha signaling were positively associated with ICDRS (Fig. 9A).