Because of no clear conclusion confirming the specific role in lung adenocarcinoma, TLR4 attracts our attention, which enables to stimulate NLRP3 inflammasomes via enhancing the activation of nuclear factor-κB (NF-κB), releasing more pro-inflammatory cytokines like IL-1β and IL-18 [35, 36]. The gene discussed is IL18; the disease is lung adenocarcinoma.