Although the specific pathological role of tau propagation and templated aggregation is still under investigation in non-AD tauopathies, the existence of tau seeding activity has been demonstrated in different experimental systems, including injection of human brain extracts in transgenic animals [28], or real-time quaking induced conversion (RT-QuIC) [13, 29, 30], for each tauopathy. Here, MAPT is linked to Alzheimer disease.