Compared with normal tissues, the expression of CNV-amplified HA regulators was significantly increased in tumor tissues (e.g. HDAC3 in KIRC), while the expression of CNV-deficient HA regulators was significantly decreased (e.g. KAT2B, HDAC11 and PBRM1 in KIRC). This evidence concerns the gene PBRM1 and neoplasm.