HDAC1 and lung cancer: As the actual fact is, growing evidence shows that the perturbations on histone acetylation are commonly observed in the cases of tumor occurrence [3–5].The “eraser” of HA HDAC1 has been reported to be highly expressed in non-small cell lung cancer (NSCLC) cell lines, and down-regulation of HDAC1 inhibits lung cancer cell proliferation, migration, invasion, tumor angiogenesis, and induces cell apoptosis [6].