Even in terms of T-cell activation, because IL-6 KO mice exhibit greater dendritic cell-mediated T-cell activation than wild-type mice [38], the differentiation and maturation of DCs are suppressed by cytokines such as TGF-β, IL-6, and IL-10 produced by tumor cells; thus, the induction of tumor antigen-specific CTLs and antitumor immune response are likely suppressed. This evidence concerns the gene TGFB1 and neoplasm.