CD274 and cancer: The results of GSEA analysis of the Go database showed that most of the genes were mainly associated with acetyltransferase complex, histone acetyltransferase complex, the establishment of RNA localization, and mRNA transport (Fig. 2c); GSEA enrichment analysis of the KEGG database was mainly associated with nucleocytoplasmic transport, T cell receptor signaling pathway, Th17 cell differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer (Fig. 2d).