In the transcriptome analysis network we constructed, ten main hub genes (TP53, MYC, AKT1, SIRT1, FOS, CEBPB, SMARCA4, FOXO3, NFE2L2, and CDKN1B) are involved in the physio-pathological interactions of end-stage renal failure and cellular senescence. The gene discussed is TP53; the disease is stage 5 chronic kidney disease.