Recent studies have also confirmed the protective effects of GLIS2 on renal cells: GLIS2 inhibits epithelial-mesenchymal transition and apoptosis of renal tubular cells by regulating the β-linked protein signaling pathway in diabetic nephropathy and ameliorates hypertension-induced renal injury by affecting autophagy through upregulation of GLIS2 expression [41, 42]. Here, GLIS2 is linked to diabetic kidney disease.