Actually, in most cases, PAX6-associated FH could be accompanied with variable iris changes: You B and colleagues found that 93% of the patients with aniridia and PAX6 mutations presented FH in their cohort; [23] a missense variant was also identified by Hingorani et al. in patients with FH and mild structural abnormalities in the iris; [1] Jiang Y and colleagues reported that in their observation of FH, full iris with subtle structural abnormalities with mutations in the C-terminal region of the PD of PAX6 [11]. The gene discussed is PAX6; the disease is isolated aniridia.