MGMT and neoplasm: In addition to light microscopy and immunohistochemistry, an arsenal of methods including MGMT-pyrosequencing, methylome profiling, panel sequencing, and in rare cases RNA sequencing has become pivotal in providing not only an integrated histopathological and molecular diagnosis, but also further data on tumor epigenetics, transcriptomics, and metabolomics that is becoming increasing relevant to therapy and prognosis.