Moreover, non-luminal HER2+ BC showed higher prevalence of apocrine histotype (P = 0.012), high grade (G3; P = 0.001), higher post-NACT prognostic stage (P = 0.029), higher values of pre-NACT TILs (P = 0.002), less frequently HER2 IHC2+ (P = 0.002) and more frequently pre-NACT AR negativity (P = 0.013). This evidence concerns the gene ERBB2 and breast cancer.